University of Colorado Anschutz Medical Campus

Advanced Research Projects Agency for Health (ARPA-H)

Advanced Research Projects Agency for Health (ARPA-H), established in 2022, supports transformative high-impact research to drive biomedical and health breakthroughs — ranging from molecular to societal — to provide transformative solutions for all patients.

Modeled after DARPA, this new federal agency represents an important potential funder for the CU Anschutz research community. With a $2.5B budget, this funding agency is expected to speed the development of treatment and cures for diseases, tacking the biggest threats to human health.

For ARPA-H questions, contact Erin Calhoun.

Open Funding Opportunities

Program	Proposer’s Day	Abstract/Solution Summary	Full Proposal
BIOmolecular Grammar for protein Aggregation Modulation and Intervention	February 20, 2026 (registration) Arlington, VA (Hybrid)	03/04/2026	04/15/2026 (By invite only)
Agentic AI-Enabled Cardiovascular Care Transformation (ADVOCATE)		2/27/2026	04/01/2026 (By invite only)
BioStabilization Systems (BoSS)	January 29, 2026 (registration) Washington D.C./Hybrid	2/19/2026	3/26/2026 (By invite only)
Autonomous Interventions and Robotics (AIR)	12/16/2025 (registration) Bethesda, MD\Hybrid	1/16/2026	3/30/2026 (By invite only)
Evidence-Based Validation & Innovation for Rapid Therapeutics in Behavioral Health (EVIDENT)	12/10/2025 (registration) Arlington, VA/Hybrid	12/22/2025	Rolling (By invite only)
Genetic Medicines and Individualized Manufacturing for Everyone (GIVE)		12/19/2025	2/27/2026 (By invite only)
Mission Office Innovative Solutions Openings*	NA	Solution Summaries Expiration: March 3, 2029 (rolling submission)	March 3, 2029

*General BAA closed on 3/14/2024 and replaced with the Mission Office Innovative Solutions Openings. See details on about the awarded projects to date.

Program	Award Data
Sprint for Women's Health	Not yet released
ADvanced Analysis for Precision cancer Therapy (ADAPT)	Not yet released
Chatbot Accuracy and Reliability Evaluation (CARE)	Not yet released
Engineering of Immune Cells Inside the Body (EMBODY)	Not yet released
Building Resilient Environments for Air and Total Health (BREATHE)	Not yet released
Transplantation of Human Eye Allografts (THEA)	Not yet released
Platform Accelerating Rural Access to Distributed and Integrated Medical Care (PARADIGM)	Not yet released
Antigens Predicted for Broad Viral Efficacy through Computational Experimentation (APECx)	Not yet released
Resilient Extended Automatic Cell Therapies (REACT) Program	Not yet released
Novel Innovations for Tissue Regeneration in Osteoarthritis (NITRO)	Not yet released
Health Innovation Network Hub and Spokes Customer Experience Hub Investor Catalyst Hub	2 Hubs Awarded Dallas Hub; CU Anschutz (Spoke) Boston Hub; UCHealth CARE Innovation Center (Spoke)
ARPA-H Digital Health Security (DIGIHEALS)	6 Awarded Projects ($51M)
Small Business Innovation Research (SBIR)	9 Awards ($33M)
Biomedical Data Fabric Toolbox (TA1-TA3) Biomedical Data Fabric Toolbox NCI Fredrick National Labs – early use cases in cancer (TA4)	Awards not yet announced
Precision Surgical Interventions (PSI) Program	Awards not yet announced

*Represents one of several spokes selected in the network

What is Proposers’ Day?
Proposer’s Days are events hosted by ARPA-H in connection with a specific funding opportunities/program, held either in-person, virtually, or both. The purpose of Proposer’s Day is to allow potential applicants to socialize research ideas with ARPA-H and receive feedback prior to submission. During these events ARPA-H provides detailed information about the funding program, clarifies submission logistics and encourages teaming among Institutions.

Should I attend proposers’ day?
ARPA-H highly encourages those interested in submitting an application to attend Proposer’s Day. In-person meetings have attendance limits, please contact Erin Calhoun if you are interested in attending a Proposer’s Day event. Virtual attendance may be available, but these events do not always allow for 1:1 meetings with ARPA-H program managers.

What is the submission timeline?
Submission details including due dates for each funding opportunity/program is provided in each funding announcement/BAA.

Do I have to submit an abstract?
Although not all funding opportunities/programs require an abstract, ARPA-H strongly encourages abstracts prior to full submission (even when not required). Make sure to read each funding announcement/BAA carefully for abstracts requirements.

What is the benefit of submitting a General BAA Abstract before the March 2024 deadline?
Submitting early has two advantages 1) for those asked to submit a full proposal, it provides more time for proposal development (2) ensures that funds for this opportunities/program are still available. This program accepts submissions on a rolling basis or until funds run out.

How should I contact a program manager?
Program managers are unable to accommodate individual requests for calls or meetings to discuss questions. The best way to receive feedback is to submit an abstract or attend a Proposer’s Day. For general inquiries, please complete the ARPA-H contact form.

Do ARPA-H abstracts need to be routed through InfoEd?

No. CU Anschutz does not require ARPA-H abstracts to be routed through InfoEd to the Office of Grants and Contracts (OGC) for review and approval. In lieu of this, the CU Anschutz Office of Research Development and Strategy, in collaboration with OGC, has implemented a simplified process for research teams to alert us of their intent to submit an abstract or full proposal to ARPAH. We request that one CU Anschutz team member please complete the Notification of ARPA-H Engagement Form.

Please note the ROM below is a sample only. Modify your ROM as appropriate for your proposal.

Cost Category	Phase I (year 1)	Phase II (years 2-)	Phase III (years 4-)	Overall Amount
Direct Labor	$12,127,546	$24,482,139	$24,777,583	$61,387,268
Subcontractors	$33,056,338	$37,776,193	$37,878,366	$108,710,896
Materials	$3,469,890	$6,974,306	$6,994,524	$17,438,720
Equipment	$14,847,000	$3,750,000	$ -	$18,597,000
Travel	$110,000	$212,000	$212,000	$534,000
Other Direct Costs	$649,150	$1,319,359	$1,333,968	$3,302,477
Indirect Costs	$3,760,722	$7,251,780	$7,449,099	$18,461,600
Profit	$ -	$ -	$ -	$ -
Cost Sharing	$ -	$ -	$ -	$ -
TOTAL	$68,020,646	$81,765,777	$78,645,540	$228,431,961

Submit your Notice of Engagement for ARPA-H

CU Anschutz does not require ARPA-H abstracts to be reviewed by OGC. In lieu of this, we request that one CU Anschutz team member please alert us through a simplified process of your intent to submit an abstract or full proposal to ARPA-H.

Submit

Office of the Vice Chancellor for Research

CU Anschutz

Fitzsimons Building

13001 East 17th Place

WG109

Mail Stop F520

Aurora, CO 80045

Associate Vice Chancellor for Research and Chief Research Officer, Philip De Leon, PhD

Tools & Resources

Schools & Colleges

CU Denver

CU Anschutz

CU Campuses

Research Development and Strategy

Office of the Vice Chancellor for Research

Advanced Research Projects Agency for Health (ARPA-H)

Open Funding Opportunities

Submit your Notice of Engagement for ARPA-H

Office of the Vice Chancellor for Research

Advanced Research Projects Agency for Health (ARPA-H)

Open Funding Opportunities

Closed Opportunities and Award Data

Frequently Asked Questions

Sample Rough Order of Magnitude (ROM)

Additional Resources

Submit your Notice of Engagement for ARPA-H

Office of the Vice Chancellor for Research