Introduced in 2025, Highlighted Topic Areas help investigators identify emerging NIH priorities and align their research with high-interest scientific areas. Researchers can submit investigator-initiated proposals through existing NIH funding opportunities while engaging early with program officers to ensure alignment and strengthen application competitiveness. Click the link below to explore all topics and their participating ICs.
Using keywords, you can search for opportunities in your area of research using Pivot-RP.
The Pivot User Guide can help you get started.
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| Title | Funder | Type | Expiration/Application | URL |
| Coccidioidomycosis Collaborative Research Centers | NIH | CCRC | P01 Clinical Trial Not Allowed | 07/09/2026 | https://simpler.grants.gov/opportunity/11303a9d-cdcf-4f67-9948-553ad3a7e04b |
| Atopic Dermatitis Research Network | NIH | NIAID | U19 Clinical Trial Optional | 09/24/2026 | RFA-AI-27-004: Atopic Dermatitis Research Network (ADRN) (U19 Clinical Trial Optional) |
| Metastasis Research Network | NIH | NCI | U54 Clinical Trial Not Allowed | 09/25/2026 | RFA-CA-27-012: Metastasis Research Network (U54 Clinical Trial Not Allowed) |
| NHLBI Program Project Applications | NIH | NHLBI | P01 Clinical Trials Optional | 09/26/2026 | https://grants.nih.gov/grants/guide/pa-files/PAR-24-065.html |
| Specialized Programs of Research Excellence (SPOREs) in Human Cancers for Years 2024, 2025, and 2026 | NIH | NCI | P50 Clinical Trial Required | 09/26/2026 | https://grants.nih.gov/grants/guide/pa-files/PAR-23-284.html |
| Biomedical Technology Optimization and Dissemination Center (BTOD) | NIH | NIGMS | RM1 - Clinical Trial Not Allowed | 09/29/2026 | PAR-27-024: Biomedical Technology Optimization and Dissemination Center (BTOD) (RM1 - Clinical Trial Not Allowed) |
| Establishing a Center for the Advancement of Substance Use Disorder (SUD) Pharmacotherapeutics through Training and Preclinical Support | NIH | NIDA | U54 Clinical Trial Not Allowed | 09/30/2026 |
Opportunity Listing - Establishing a Center for the Advancement of Substance Use Disorder (SUD) Pharmacotherapeutics through Training and Preclinical Support (U54 Clinical Trial Not Allowed) |
| Validation Center for Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) | NIH | Common Fund | U54 Clinical Trial Not Allowed | 10/02/2026 | RFA-RM-27-014: Validation Center for Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) (U54 Clinical Trials Not Allowed) |
| Nutrition Obesity Research Centers (NORCs) | NIH | NIDDK | P30 Clinical Trial Optional | 10/20/2026 | RFA-DK-27-120: Nutrition Obesity Research Centers (NORCs) (P30 Clinical Trial Optional) |
| National Center for Construction Safety and Health Research and Translation | NIH/CDC | U54 | 12/1/2026 | https://grants.nih.gov/grants/guide/rfa-files/RFA-OH-24-001.html |
| Silvio O. Conte Digestive Diseases Research Core Centers | NIH | P30 Clinical Trial Optional | 02/10/2027 | |
| National Cooperative Drug/Device Discovery/Development Groups (NCDDG) for the Treatment of Mental Disorder | NIH | NIMH | U19 Clinical Trial Optional | 10/26/2027 | https://grants.nih.gov/grants/guide/pa-files/PAR-25-353.html |
| NIAID Investigator Initiated Program Project Applications | NIH | NIAID | P01 (Clinical Trial Now Allowed) | 05/25/2029 | https://simpler.grants.gov/opportunity/9b4ae9e9-8f44-494c-9f45-95774b2c84f4 |
*Note that the following forecasted funding opportunities have been recently released under a new announcement type and are only available on the Grants.gov site with limited information. If you are interested in submitting, please contact your NIH program officer and subscribe to updates using your email address under each funding opportunity.
https://grants.gov/search-grants
| Funder | Type | Title | Release Date | URL |
| NIH | Enhancement and Management of Established Biomedical Data Repositories and Knowledgebases (R24 Clinical Trial Not Allowed) | 07/24/2026 | https://simpler.grants.gov/opportunity/e0cc79e9-8179-4567-9776-7dc57f4e8e3c | |
| NIH | NIH Blueprint Initiative: Tools for Germline Gene Editing in the Nervous System | 08/10/2026 | https://simpler.grants.gov/opportunity/9560959b-f3b5-4d8e-9306-8d87996ed72a | |
| NIH | NIDA Core "Center of Transformative Science" Grant Program | 08/18/2026 | https://simpler.grants.gov/opportunity/b5b9d054-554e-47b1-a1ba-1e302c6e6589 | |
| NIH | NCI Research Specialist (Clinician Scientist) Award (R50 Clinical Trial Not Allowed) | 08/25/2026 | https://simpler.grants.gov/opportunity/2b529176-2d03-42a4-8057-4736a55db1be | |
| NIH | The NIA Genetics of Alzheimer's Disease Data Storage Site (NIAGADS) | 09/01/2026 | https://simpler.grants.gov/opportunity/7a4a9822-f39f-464d-8a1d-d941afaebcdf | |
| NIH | Exploratory Clinical Trial Grants in Arthritis and Musculoskeletal and Skin Diseases | 09/01/2026 | https://simpler.grants.gov/opportunity/63297aa2-31d7-48db-bf60-0be097b1e40f | |
| NIH | NCI Research Specialist Award for Core and Laboratory-based Scientists (R50 Clinical Trial Not Allowed) | 09/17/2026 | https://simpler.grants.gov/opportunity/328db24c-35c9-42ea-91b0-acfcb3aeb6de | |
| NIH | National Centers for Biomedical Imaging and Bioengineering (NCBIB) (P41 Clinical Trials Optional) | 09/26/2026 | https://simpler.grants.gov/opportunity/3e9fb0bc-ebab-45f3-aacf-906b0ebb446c | |
| NIH | Intervention Research to Improve Native American Health | 10/22/2026 | https://simpler.grants.gov/opportunity/3a152e00-fe8e-4e29-b30e-efc659bb83dd | |
| NIH | Multi-Site Investigator-Initiated Clinical Trials (Collaborative UG3/UH3 Clinical Trial Required) | 11/16/2026 | https://simpler.grants.gov/opportunity/23a356f5-2b12-4891-a251-d01db68c7582 | |
| NIH | Research Resource for a National Swine Resource and Research Center (U42 Clinical Trial Not Allowed) | 11/25/2026 | https://simpler.grants.gov/opportunity/73712c84-83f0-4442-8b58-7b75836a9596 | |
| NIH | National Biomedical Research Centers (P50 Clinical Trial Optional) | 11/25/2026 | https://simpler.grants.gov/opportunity/23edd3f8-80e8-4537-b9ba-d0b852b29deb | |
| NIH | Pragmatic Trials Conducted in Health Care Systems | 11/24/2026 | https://simpler.grants.gov/opportunity/106cd2d3-4fa8-4b20-a519-4eed2b256b3c | |
| NIH | Feasibility Studies to Inform the Design of Future Clinical Trials | 11/24/2026 | https://simpler.grants.gov/opportunity/b08f815b-a840-48cb-bd2e-62caa8fd5482 | |
| NIH | Establishing a Research Network to Guide Foundational Research on Human Consciousness | 12/01/2026 | https://simpler.grants.gov/opportunity/e62cf002-ae6f-43c5-a5d2-780e7877f0c6 | |
| NIH | Digital Health Technology and Reciprocal Innovation to Improve Clinical and Public Health Outcomes | 12/01/2026 | https://simpler.grants.gov/opportunity/52596a75-bd24-4f15-a996-b8fae56e392c | |
| NIH | Limited Competition: The NHGRI Analysis, Visualization, and Informatics Lab-space (AnVIL) (U54 Clinical Trial Not Allowed) | 02/01/2027 | https://simpler.grants.gov/opportunity/1205cb8b-2fda-44bd-b04f-11ba98a5635c | |
| NIH | BRAIN Initiative: Development and Validation of Novel Tools and New Approaches for Neuroscience Research | 02/10/2027 | https://simpler.grants.gov/opportunity/59fa608f-e4ca-4ca9-b06c-6b499711f535 | |
| NIH | Claude D. Pepper Older Americans Independence Centers | 05/01/2027 | https://simpler.grants.gov/opportunity/18488b3f-1307-44af-90c9-c9bd13a857c0 | |
| NIH | A Holistic Approach to Study Non-Addictive Natural Products for Pain Management | 02/02/2027 | https://simpler.grants.gov/opportunity/bfdf98bd-f2ab-4070-bce9-fd7dedb57e31 | |
| NIH | UH2/UH3 Clinical Trial Not Allowed | Assay Validation of High Quality Markers for Clinical Studies in Cancer | 2/8/2027 | https://simpler.grants.gov/opportunity/d73ae356-f2bf-46e2-9838-207e1e01c400 |
| NIH | Limited Competition: NIGMS Mature Synchrotron Resources for Structural Biology | 10/13/2026 | https://simpler.grants.gov/opportunity/db77b347-3d04-44b2-9ecd-ad04c0d896bd |