Volume 3, Issue 4 | March 8, 2023

A Randomized Parallel Comparison of Semaglutide versus Placebo on Intestinal Barrier

Participants will complete 7-8 visits. Some participants will be asked to split screening into two visits. After screening, participants will be given either semaglutide or a placebo and will be asked to self-administer the medication once weekly. Four visits will include blood draws and three visits will include a frequently sampled urine test. Participants will also be asked to provide a stool sample after screening and at their final in-person visit. Participants should be type 2 diabetic and be treated with metformin only.

Skeletal Response to Simulated Night Shift (SPOTLIGHT Study)

Healthy men & women are needed for a research study!
Inclusion Criteria: 

• 20-40 years old
• Habitually sleep 7-9 hours/night
• Have not done night shift work in the past year
• Fully vaccinated against SARS-CoV-2

Pathophysiology of Muscle Trigger Points

Men and Women volunteers needed for a research study investigating painful and non-painful muscle. Seeking individuals who are generally healthy and either experience or free from regular tension headaches and aged between 18-59.

Randomized Phase I/II Study of the Safety and Immunogenicity of a Single Dose of the Recombinant Live-Attenuated Respiratory Syncytial Virus (RSV) Vaccines

We are looking for families with children aged between 6 and 24 months to an attenuated live virus vaccine for human respiratory syncytial virus (RSV) as part of the 5th enrollment season of a double-blind, randomized, and placebo-controlled study.

How Does Inflammation Affect the Aging Brain? Research Study Investigates Aging, Memory, and Immune Function

The University of Colorado Anschutz Medical Campus is looking for interested adults 60 and over to participate in a research study examining how inflammation influences brain health. Data gathered from this study will be used to better understand how inflammation may or may not disrupt thinking and memory. Participation involves two research visits over the course of two years.
Procedures Include:

• Memory and thinking tests
• Health history questionnaires
• Blood sample
• Spinal fluid sample
• MRI of brain
• SARS-CoV-2 antibody test (results provided)

Eligibility:

• 60 years or older
• In good general health
• Have NOT been diagnosed with a memory disorder

Neuronal and Behavioral Effects of an Implicit Priming Approach to Improve Eating Behaviors in Obesity

To be eligible for the study, participants must be between 18-65 years old, have a BMI between 25-45, and be able to complete an MRI scan.

Seeking Healthy Postmenopausal Women Volunteers

Healthy postmenopausal women volunteers (55-75 years) are needed for an observational study. Two visits (screening [1.5 hrs] and testing [3 hrs]).

Research about the Potential for the Contraceptive Implant as Emergency Contraception

To research more about ovulation (the process of egg release from the ovary) in the setting of recently placed etonogestrel implants (Nexplanon®).

The Influence of Combined Oral Contraceptives on Weight: A 6-months Observational Study

Eligibility:

• Female
• 18-40 years old
• BMI between 25-45
• Generally healthy
• Not currently using a hormonal form of birth control and willing to start and continue the Sprintec pill for 6 months

SESAD – Alzheimer’s Clinical Trial

The purpose of this research study is to learn more about the safety and effectiveness of a drug called sargramostim for improving cognitive function and memory in people with Alzheimer's disease. Participants will be asked to participate in weekly visits for 24 weeks (6 months), as well as screening and follow-up visits. Weekly appointments will be conducted at the University of Colorado Anschutz Medical Campus in Aurora, Colorado. Compensation Provided. Study related care and medication at no cost.  These visits may include some of the following procedures:Cognitive testing, Twice weekly blood draws, Health Questionnaires, Study Partner Questionnaires, Lumbar Puncture (spinal tap), MRI, PET scan, Treatment/placebo injection 5x a week during treatment phase.
Eligibility:

• Age between 60-80 years.
• Have a diagnosis of mild-to-moderate Alzheimer's disease (AD).
• Willing and able to have a lumbar puncture (spinal tap) and twice weekly blood draws.
• Not have a first degree relative diagnosed with AD before 55 years of age.
• Have a study partner willing to give daily injections after training.