Volume 3, Issue 2 | February 8, 2023

Colorado Pulmonary Alcohol Research Consortium

We are looking for volunteers to serve as control subjects to be compared to people who drink heavily in a research project that examines substances collected from inside the lungs.
Main Procedures Involved:

• Thorough pulmonary evaluation by a lung physician by physical exam, chest x-ray, spirometry, and bronchoscopy.
• Routine blood lab work & pregnancy test will be performed

Duration of Participation:

• A single study visit from 7 AM to 12 PM during a weekday.
• Participants will need a negative COVID test 3-5 days before their visit.

Skeletal Response to Simulated Night Shift (SPOTLIGHT Study)

Eligibility:

• Healthy men and women aged 20-40 years old.
• Habitually sleep 7-9 hours/night.
• Have not done night shift work in the past year.
• Do not currently smoke.
• Fully vaccinated against SARS-CoV-2

The Influence of Combined Oral Contraceptives on Weight: A 6-months Observational Study

• Female
• 18-40 years old
• BMI between 25-45
• Generally healthy
• Not currently using a hormonal form of birth control and willing to start and continue the Sprintec pill for 6 months

Seeking Healthy Postmenopausal Women Volunteers

Healthy postmenopausal women volunteers (55-75 years) are needed for an observational study. Two visits (screening [1.5 hrs] and testing [3 hrs]).

How Does Inflammation Affect the Aging Brain? Research Study Investigates Aging, Memory, and Immune Function

The University of Colorado Anschutz Medical Campus is looking for interested adults 60 and over to participate in a research study examining how inflammation influences brain health. Data gathered from this study will be used to better understand how inflammation may or may not disrupt thinking and memory. Participation involves two research visits over the course of two years.
Procedures Include:

• Memory and thinking tests
• Health history questionnaires
• Blood sample
• Spinal fluid sample
• MRI of brain
• SARS-CoV-2 antibody test (results provided)

Eligibility:

• 60 years or older
• In good general health
• Have NOT been diagnosed with a memory disorder

Research about the Potential for the Contraceptive Implant as Emergency Contraception

To research more about ovulation (the process of egg release from the ovary) in the setting of recently placed etonogestrel implants (Nexplanon®).

DHEA Augmentation of Musculoskeletal Adaptations to Exercise in Older Women

Inclusion Criteria:

• Healthy postmenopausal women aged 55-85 years
• Willing to take DHEA or inactive placebo every day for 9 months
• Willing to exercise 3x per week at the Anschutz Medical Campus
• Fully vaccinated and boosted against COVID-19

Exclusion Criteria:

• Currently taking osteoporosis medication
• Currently using hormone therapy
• History of breast cancer
• Current use of tobacco products
• Inability to complete MRI scan
• Use of Insulin

ImTAB- Immunity, mTBI, and Alzheimer's Biomarkers

The University of Colorado Anschutz Medical Campus is looking for interested adults to participate in a research study examining how a concussion sustained later in life relates to inflammation and brain health. The goal of this study is to better understand how a concussion sustained later in life relates to inflammation, the aging process, and risk for future memory problems. This study involves 2 research visits: a baseline and a one year follow-up visit at the University of Colorado Anschutz Medical Campus. Compensation provided. Each Study Visit Requires:

• Health History Review
• Neurological Exam
• Thinking and memory tests
• Blood Sample
• Brain MRI

Inhaled Cannabis, Oxidative Stress and the Pulmonary Innate Immune Response

This study evaluates the effect of long term cannabis/marijuana smoking on lung health. Volunteers should be between ages 21-55.

ARROW - Adaptive Responses to Overfeeding and Weight

Research Volunteers needed for 1 year research study looking at your body's response to dietary changes after completing FREE weight loss program.

ColorAdo ReseArch on Menopause & Early Life Stress Study: Remote Participation

Study participation consists of five study sessions (all completed virtually from your home), over the course of 2 months. These visits will consist of questionnaires about your mood and some stressful life events; thinking and mood assessments; collection of hair, saliva, and blood microsamples; and a stress task.

SESAD – Alzheimer’s Clinical Trial

The purpose of this research study is to learn more about the safety and effectiveness of a drug called sargramostim for improving cognitive function and memory in people with Alzheimer's disease. Participants will be asked to participate in weekly visits for 24 weeks (6 months), as well as screening and follow-up visits. Weekly appointments will be conducted at the University of Colorado Anschutz Medical Campus in Aurora, Colorado. Compensation Provided. Study related care and medication at no cost.  These visits may include some of the following procedures:Cognitive testing, Twice weekly blood draws, Health Questionnaires, Study Partner Questionnaires, Lumbar Puncture (spinal tap), MRI, PET scan, Treatment/placebo injection 5x a week during treatment phase.
Eligibility:

• Age between 60-80 years.
• Have a diagnosis of mild-to-moderate Alzheimer's disease (AD).
• Willing and able to have a lumbar puncture (spinal tap) and twice weekly blood draws.
• Not have a first degree relative diagnosed with AD before 55 years of age.
• Have a study partner willing to give daily injections after training.