COVID-19 Active Studies

COMIRB #	PI	Title	Open to Accrual (OTA) Date	Closed to Accrual Date
20-0781	Anna Maw	COVID-19: Lung ultrasound implementation in the management of patients with COVID-19	4/14/2020	N/A
20-0685	Thomas Flaig	COVID-19 Biobank	4/21/2020	N/A

COMIRB #	PI	Title	Open to Accrual (OTA) Date	Closed to Accrual Date
20-0880	Ernest Moore	STARS ("Study of Alteplase for Respiratory failure in SARS-Cov2 (COVID-19)", a Phase IIa Clinical Trial	5/27/2020	N/A

COMIRB #	PI	Title	Open to Accrual (OTA) Date	Closed to Accrual Date
20-1227	Adit Ginde	Trial of Early Antiviral Therapies during Non-hospitalized Outpatient Window (TREAT NOW) for COVID-19	6/8/2020	N/A
20-1197	Thomas Flaig	COVID-19 Prospective Observational Cohort Study and Biobank of Health Care Workers and Other Populations	6/11/2020	N/A

COMIRB #	PI	Title	Open to Accrual (OTA) Date	Closed to Accrual Date
20-1219	Brent Palmer	SARS-CoV-2 specific T cell responses in HIV-positive and negative individuals after resolution of COVID-19 viral infection	7/1/2020	N/A

COMIRB #	PI	Title	Open to Accrual (OTA) Date	Closed to Accrual Date
20-1708	Eric Simoes	A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study Assessing the Efficacy and Safety of Anti-Spike SARS-CoV-2 Infection in Household Contacts of Individuals Infected with SARS-CoV-2	8/14/2020	N/A
20-0751	Jose Diaz-Miron	The Use of Ultrasound in Establishing COVID-19 Infection as Part of a Trauma Evaluation	8/26/2020	N/A

COMIRB #	PI	Title	Open to Accrual (OTA) Date	Closed to Accrual Date
20-1650	Ellen Burnham	I-SPY COVID TRIAL: An Adaptive Platform Trial to Reduce Mortality and Ventilator Requirements for Critically Ill Patients	9/4/2020	N/A
20-1905	Adit Ginde	A Multicenter, Adaptive, Randomized, Blinded, Controlled Trial of the Safety and Efficacy of Investigational Therapeutics for Hospitalized Patients with COVID-19	9/8/2020	N/A
20-0852	Natasha Altman	Myocardial Virus and Gene Expression in SARS CoV-2 Positive Patients with Clinically Important Myocardial Dysfunction	9/9/2020	N/A
20-1859	Thomas Campbell	Adaptive Platform Treatment Trial for Outpatients with COVID-19 (Adapt Out COVID)	9/15/2020	N/A
20-1183	Ali Musani	COVID19 Aerosolization Pilot Study	9/22/2020	N/A
20-1452	Marc Moss	Biology and Longitudinal Epidemiology of PETAL COVID-19 Observational Study	9/22/2020	N/A

COMIRB #	PI	Title	Open to Accrual (OTA) Date	Closed to Accrual Date
20-1339	Jose Diaz-Miron	In-Utero Vascular Accidents in Neonates from COVID-19 Infected Mothers	10/2/2020	N/A

COMIRB #	PI	Title	Open to Accrual (OTA) Date	Closed to Accrual Date
20-1406	Steve Moulton	CRI and Continuous Assessment of Hemodynamic Compensation to Guide Fluid and Pressor Management in Severely Ill Patients with COVID-19	11/13/2020	N/A
20-2367	Thomas Campbell	A Phase 3, Randomized, Observer-Blinded, Placebo-Controlled Study to Evaluate the Efficacy, Safety, and Immunogenicity of a SARS-CoV-2 Recombinant Spike Protein Nanoparticle Vaccine (SARS-CoV-2 rS) with Matrix-M1™ Adjuvant in Adult Participants ≥ 18 years	11/13/2020	N/A
20-2362	Natalie Held	Understanding Provider Cognitive Load During Intensive Care Unit Rounds	11/25/2020	N/A

 

COMIRB #	PI	Title	Open to Accrual (OTA) Date	Closed to Accrual Date
20-2972	Mark Nehler	Assessing Safety, Hospitalization and Efficacy of rNAPc2 in COVID-19 (ASPEN-COVID-19)	12/10/2020	N/A
20-2864	Thomas Jaenisch	A Proof of Concept Study on Detection of SARS-CoV-2 in Exhaled Ait in Symptomatic/Asymptomatic Persons Using Innovative, Non-Invasive Embedded Strips in Masks - Phase 1	12/10/2020	N/A
20-3047	Hemali Patel	Monitoring hospital patients through wearable digital device sensor data	12/22/2020	N/A

 

COMIRB #	PI	Title	Open to Accrual (OTA) Date	Closed to Accrual Date
20-1519	Sunita Sharma	Systemic Anticoagulation with Full Dose Low Molecular Weight Heparin (LMWH) Vs. Prophylactic or Intermediate Dose LMWH in High Risk COVID-19 Patients (HEP-COVID Trial)	2/24/2021	N/A

COMIRB #	PI	Title	Open to Accrual (OTA) Date	Closed to Accrual Date
20-1088	Robert Kowalski	Evaluation of ultra-early microRNA and metabolomic biomarkers in acute ischemic stroke	3/18/2021	N/A
21-2935	Adit Ginde	Real-world effectiveness and safety of nMAb treatment in high-risk COVID-19 outpatients	3/26/21	N/A

COMIRB #	PI	Title	Open to Accrual (OTA) Date	Closed to Accrual Date
21-2608	Eric Simoes	A PHASE 2/3 PLACEBO-CONTROLLED, RANDOMIZED, OBSERVER-BLIND STUDY TO EVALUATE THE SAFETY, TOLERABILITY, AND IMMUNOGENICITY OF A SARS-COV-2 RNA VACCINE CANDIDATE (BNT162b2) AGAINST COVID-19 IN HEALTHY PREGNANT WOMEN 18 YEARS OF AGE AND OLDER	4/8/2021	N/A
20-2673	Jacinda Nicklas	MET-COVID Trial - METformin for Post-exposure prophylaxis (PEP) and outpatient treatment of COVID-19: Does Metformin prevent severe COVID-19 disease?	4/15/2021	N/A
20-2986	Sarah Jolley	A Phase 2 Study of BIO 300 Oral Suspension in Discharged COVID-19 Patients	4/22/2021	N/A

COMIRB #	PI	Title	Open to Accrual (OTA) Date	Closed to Accrual Date
21-3107	Sarah Jolley	Functional, imaging, and respiratory evaluation in CORAL: FIRE CORAL	5/11/2021	N/A
20-1989	Adriana Weinberg	Pharmacokinetics and Safety of Remdesivir for Treatment of COVID-19 in Pregnant and Non-Pregnant Women in the United States	5/18/2021	N/A

COMIRB #	PI	Title	Open to Accrual (OTA) Date	Closed to Accrual Date
21-2690	Adit Ginde	Human intravenous Interferon Beta-1a Safety and preliminary efficacy in hospitalized subjects with CoronavirUS (HIBISCUS)	7/13/2021	N/A
21-3315	Ellen Burnham	Electrical Impedance Tomography for Assessing Respiratory Improvement in Hospitalized COVID-19 Patients	7/26/2021	N/A

COMIRB #	PI	Title	Open to Accrual (OTA) Date	Closed to Accrual Date
20-0615	Thomas Campbell	An Adaptive Phase 2/3, Randomized, Double-Blind, Placebo-Controlled Study Assessing Efficacy and Safety of Sarilumab for Hospitalized Patients with COVID-19 Sponsor Protocol No. 6R88-COV-2040	3/23/2020	7/02/2020
20-0616	Thomas Campbell	A Phase 3 Randomized Study to Evaluate the Safety and Antiviral Activity of Remdesivir (GS-5734)™ in Participants with Severe COVID-19 (GS-US-540-5773	3/27/2020	5/29/2020
20-0167	Thomas Campbell	A Phase 3 Randomized Study to Evaluate the Safety and Antiviral Activity of Remdesivir (GS-5734™) in Participants with Moderate COVID-19 Compared to Standard of Care Treatment (GS-US-540-5774)	3/27/2020	5/29/2020
20-0934	Thomas Campbell	Phase 3 randomized, double-blind, placebo-controlled, multi-center study to assess the efficacy and safety of ruxolitinib in patients with COVID-19 associated cytokine storm (RUXCOVID)	5/26/2020	9/18/2020
20-0951	Thomas Campbell	A Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Efficacy of Hydroxychloroquine and Azithromycin to Prevent Hospitalization or Death in Persons with COVID-19	5/29/2020	6/17/2020
20-0930	Thomas Campbell	A multi-center, randomized, double-blinded, placebo-controlled multicenter study to evaluate the safety and efficacy of hydroxychloroquine monotherapy and in combination with azithromycin in patients with moderate and severe COVID-19 disease	6/2/2020	6/19/2020
20-1475	Thomas Campbell	A master protocol assessing the safety, tolerability, and efficacy of anti-spike (s) SARS-CoV-2 monoclonal antibodies for the treatment of hospitalized patients with COVID-19	6/16/2020	5/18/2021
20-1476	Thomas Campbell	A MASTER PROTOCOL ASSESSING THE SAFETY, TOLERABILITY, AND EFFICACY OF ANTI-SPIKE (S) SARS-COV-2 MONOCLONAL ANTIBODIES FOR THE TREATMENT OF AMBULATORY PATIENTS WITH COVID-19	7/1/2020	5/18/2021
20-1619	Thomas Campbell	A Phase 3, Randomized, Stratified, Observer-Blind, Placebo-Controlled Study to Evaluate the Safety, Efficacy, and Immunogenicity of mRNA-1273 SARS-CoV-2 Vaccine in Adults Aged 18 Years and Older	8/12/2020	10/23/2020

 

COMIRB #	PI	Title	Open to Accrual (OTA) Date	Closed to Accrual Date
20-0736	Marc Moss (previously Adit Ginde)	Hydroxychloroquine for the Early Treatment of COVID-19 in Hospitalized Adults: A Multicenter Randomized Clinical Trial (ORCHID)	4/16/2020	6/19/2020

 

COMIRB #	PI	Title	Open to Accrual (OTA) Date	Closed to Accrual Date
20-0803	Adit Ginde	COVID-19 Surveillance in Healthcare Workers and ICU Patients: Observational Studies from the Influenza Vaccine Effectiveness in the Critically Ill (IVY) Network	4/14/2020	4/16/2020
20-1693	Adit Ginde	Clinical Trial of COVID-19 Convalescent Plasma in Outpatients (C3PO)	8/11/2020	3/9/2021
20-2149	Adit Ginde	Passive Immunity Trial for Our Nation	10/1/2020	6/1/2021

 

COMIRB #	PI	Title	Open to Accrual (OTA) Date	Closed to Accrual Date
20-0986	David Beckham	An Observational Cohort Trial of outcomes and antibody responses following treatment with COVID19 Convalescent plasma in hospitalized COVID-19	4/27/2020	8/20/2020
20-0990	David Beckham	Convalescent Plasma for the Treatment of Patients with COVID-19	4/29/2020	8/26/2020

 

COMIRB #	PI	Title	Open to Accrual (OTA) Date	Closed to Accrual Date
20-0885	Phoebe Montgomenry (DH PI), Jessica Anderson & Denise Smith (UCD)	The role of shared decision-making in care of obstetric patients with suspected or confirmed SARS-CoV-2 and infants, and the impact on health outcomes	5/8/2020	12/31/2020

COMIRB #	PI	Title	Open to Accrual (OTA) Date	Closed to Accrual Date
20-2058	Brian Harry	Saliva for detection of SARS-CoV-2	8/20/2020	3/31/2021

 

COMIRB #	PI	Title	Open to Accrual (OTA) Date	Closed to Accrual Date
20-1897	Andrew Monte	A Randomized Double Blind, Placebo-Controlled Study of Auxora for the Treatment of Severe COVID-19 Pneumonia (CARDEA)	10/9/2020	3/5/2021